P6 Extreme – 50/100 Capsules
Testosterone Boosting – Hypertrophic Agent

Quick Facts:

• Elevates Free Testosterone
• Blocks Estrogen & DHT Conversion
• Increases Strength & Lean Mass
• Stimulates Healthy Libido
• Enhances Athletic Performance

Increasing testosterone is the most critical factor in building muscle. P6 Extreme is the most androgenic and anabolic testosterone booster ever created. The superior formula uses a rare and potent blend of testosterone enhancing compounds that have been shown to rapidly increase free testosterone levels.

P6 Extreme was designed to block estrogen, generating even higher levels of free testosterone while also reducing the likelihood of hair loss, acne, and gynecomastia. The end result is a substantial increase in strength, power and lean muscle mass.

P6 Extreme is frequently used by elite athletes as a safe and legal alternative to steroids or as a post cycle therapy product for body builders.

Raw Ingredients

• Ovine Placental Powder
• Tribulus terrestris
• Beta-sitosterol
• Cimicifuga racemosa
• Agaricus bisporus
• Eurycoma longifolia
• 3,4-divanillyltetrahydrofuran
• Dihydroxy Diosgenin
• Sclareolide

What is P6 Extreme?

P6 Extreme was designed to enhance natural testosterone production via multiple biological pathways. It harnesses biological processes through orthologous hormones, provides plant-based phytosterols, enhances the rate at which the body synthesizes testosterone, and inhibits factors that limit testosterone production. P6 Extreme enhances natural testosterone levels while preventing the harmful side effects associated with other similar products.

Human Chorionic Gonadotropin (hCG) has been used clinically as a pharmaceutical agent in the treatment of hypogonadism as well as to increase fertility. hCG works by activating the Luteinizing Hormone/Choriogonadotropin (LHCG) receptors of the pituitary gland. The activation of these receptors causes the body to release a large surge of luteinizing hormone (LH) from the pituitary gland, similar to the onset of puberty. It then sends a chemical signal to the testes to increase steroidogenesis (production of androgen hormones) and sperm production in males.
 

The primary active component of P6 Extreme is Equine Chorionic Gonadotropin (eCG), found in high concentrations in Ovine Placenta Powder. eCG acts as an orthologous hormone to hCG and causes the same LH surge and increase in both testosterone and fertility.

The active components of Tribulus terrestris and Eurycoma longifolia are Protodioscin and Eurypeptides, respectively. These components have been shown to increase the levels of dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and testosterone while also increasing body weight and sexual function. The research to determine the exact mechanism of Eurypeptides action is ongoing.

The T. terrestris compound, Protodioscin, has a structure that is similar to androgen hormones and has been theorized to undergo biotransformation into DHEA, subsequently increasing both testosterone and DHT levels.

The active components of both T. terrestris and E. longifolia show definite anabolic effects on muscle growth by either supplying precursors or increasing precursor availability and abundance.
 

P6 Extreme influences the conversion of cholesterol into other steroid hormones, including testosterone, by altering the functions of genes related to cholesterol metabolism. Steroidogenic acute regulatory protein (StAR) is the transport protein that shuttles cholesterol into the mitochondria of the cell for conversion into steroid hormones, a process known as steroidogenesis. Cyclic adenosine monophosphate (cAMP) is a key signaling molecule in this process and its cellular concentration is enhanced by Sclareolide.

The sudden increase in cAMP levels increases the production of StAR by binding to its promoter region. This event causes the rate at which cholesterol is converted to testosterone to increase dramatically. This occurrence is another aspect by which P6 Extreme enhances the amount of testosterone naturally synthesized in the body.

Other factors can be rate limiting in testosterone production: the presence of sex-hormone binding globulin (SHBG) and the enzymes of the Cytochrome P450 3A (CYP450 3A) family.
 

The compound 3,4-divanillyltetrahydrofuran found in P6 Extreme can actively bind to SHBG and block its function as the rate-limiting transport protein of androgenic hormones. With SHBG inhibition, testosterone can enter the cell at a much faster rate. Unbound testosterone can permeate the cell more freely due to its smaller molecular size.

The CYP450 3A enzymes are responsible for the recognition and breakdown of overly abundant chemicals (in many cases, foreign drugs) in the body. The inhibition of these enzymes is carried out by the Triterpene Glycosides found in Cimicifuga racemosa, an integral component of P6 Extreme. These compounds undergo structural transformations that mimic the structures of hormone molecules and act as competitive inhibitors of the CYP450 3A enzymes.

Many different enzymes and regulatory proteins can limit the ability of testosterone to undergo metabolism in the body. The aromatase enzyme is responsible for the conversion of androgen hormones, like testosterone, into estrogenic hormones.
 

Certain compounds can act as competitive enzyme inhibitors that allow higher levels of free testosterone to circulate in the body. Some compounds can act as mechanism-based inhibitors, binding aromatase and causing structural changes that damage and prevent this enzyme from binding to testosterone. Additionally, in P6 Extreme, there are also mutagenic inhibitors. Mutagenic inhibitors actually alter the amino acid sequence of the aromatase enzyme. Such mutations result in a total loss of function to convert androgens into estrogens.

P6 Extreme contains Agaricus bisporus extract (which contains significant concentrations of mutagenic inhibitors) to inhibit aromatase. Another enzyme known as 5-alpha reductase converts testosterone into DHT. P6 Extreme utilizes ßeta-sitosterol to inhibit 5-alpha reductase, preventing DHT conversion.

Aromatase and 5-alpha reductase cause undesired side effects of testosterone supplementation, including oily skin, acne, gynecomastia, and male-patterned baldness. Such side effects are avoidable completely if aromatase and 5-alpha reductase are inhibited properly as they are in P6 Extreme.

Cholesterol can be formed from metabolized androgens. High cholesterol levels are associated with an elevation of low-density lipoproteins (LDL), potentiating the risk of cardiovascular disease. However, the use of the compound Dihydroxy Diosgenin in P6 Extreme has been shown to reduce both LDL and overall triglyceride levels in the blood.