N0 Extreme successfully boost nitric oxide from 7 different sources, one of those
sources being a revolutionary breakthrough compound called NCG. NCG is an amino acid
derivative that increases growth hormone levels and protein synthesis while drastically
increasing nitric oxide.
N0 Extreme is also the first and only extremely potent pre-workout product not containing
creatine. N0 Extreme increases carnosine through the use of carnosine pre-cursors,
Beta Alinine and Histidine. Each dose provides an intense, sustainable boost of energy
and focus geared to get you through your most grueling workouts.
Just like M5 Extreme, N0 Extreme is precision dosed into 36 individual pouches preventing
the clumping and caking associated with most powder supplements. N0 Extreme is available
in a mouth-watering Orange and a delicious and refreshing Fruit Punch.
Raw Ingredients
- Arginine-AKG
- N-carbamylglutamate (NCG)
- Citrulline-Malate
- Leucine
- Beta-Alanine
- Caffeine
- Histidine
- Ornithine-AKG
- Isoleucine
- Valine
- Arginine-Picamilon
- Norvaline
- Theobromine
- Magnesium Tashinoate B (MTB)
- Methyltyramine
- Methylsynephrine
- Oxovanadium
- Vinpocetine
What is N0 Extreme?
N0 Extreme was designed to be one of the first multi-faceted,
extremely potent, pre-workout supplements in existence. This formulation is one of
the first of many alternatives to a creatine-free supplement that is highly conducive
to muscle growth, while obtaining comparable strength gains to creatine-containing
products due to its generation of high ATP levels.
N0 Extreme utilizes nitric oxide
boosting from seven different angles, provides carnosine precursors for maximizing
ATP levels, supplies pre-workout branched-chain amino acids, and provides an energy
boost unlike anything previously designed.
N0 Extreme is unique in the fact that it uses Arginine-AKG, Citrulline-Malate, and
Ornithine-AKG to increase nitric oxide via the inducible Nitric Oxide Synthase (iNOS)
enzyme at different time intervals. N0 Extreme also utilizes the endothelial NOS/constitutive
NOS (eNOS/cNOS) enzyme in NO production via the use of Magnesium Tashinoate B (MTB).
The amino acid derivative norvaline also helps prevent the breakdown of the body’s
endogenous levels of Arginine (the direct precursor of NO). One of the newest NO-boosting
compounds to enter the nutraceutical market, N-carbamylglutamate, is also infused
into N0 Extreme, along with Cellucor’s first ever-designed Arginine-Picamilon compound.
This combination of NO-enhancing agents induces unparalleled vascularity for strength
and endurance.
Activating iNOS is accomplished via Arginine through the NO Cycle
(i.e., Arginine -> Citrulline and NO OR -> Ornithine -> Citrulline -> Arginosuccinate
OR Citrulline -> Arginine and diatomic oxygen -> Agmatine OR recirculation of Arginine
through the cycle).
Arginine is a requirement for all nitric oxide production via the iNOS enzyme. The
Arginine metabolite, Agmatine, also has vasodilating effects, but can inhibit iNOS
as well. Using Citrulline and Ornithine provide additional Arginine precursors that
become nitric oxide, and create a time-released effect due to the different biological
conversions that must take place.
The Malate and Alpha Ketoglutarate (AKG) moieties
on these particular NO precursors in N0 Extreme have a two-fold effect. Both Malate
and AKG are particular intermediates in the Tri-Carboxylic Acid (TCA) cycle. This
cycle occurs in the mitochondria of all cells of the body and is responsible for
the metabolism of nutrients from food (protein, carbohydrates, and fats) into usable
energy in the form of ATP. The bonds on theses NO precursors enhance ATP production
within the cell; since both Malate and AKG are intermediates in the TCA cycle, they
are recognized and taken up quickly by the cell. The NO precursors that are complexed
with these TCA intermediates become uncoupled in the mitochondria, and are released
back into the cell to participate in biological processes.
N0 Extreme also activates the cNOS enzyme through MTB. The activation of cNOS occurs
commonly when calcium is abundant and produces NO through its metabolites, nitrite
and nitrate. Nitrates are found typically in most plant matter that is consumed in
the diet, and the use of synthetic nitrates has reached pharmaceutical status in
blood pressure medications.
MTB is the active component of S. miltiorrhiza, the common
Chinese Danshen. Clinically, MTB has been shown to increase the release of NO metabolites
from endothelial cells. When these nitric oxide metabolites are released into the
bloodstream, the cNOS enzymes quickly recognize and metabolize them into nitric oxide.
The next step that N0 Extreme takes in maximizing nitric oxide production is to limit
the main enzyme, Arginase, which is responsible for catabolizing overly abundant
Arginine. The amino acid derivative, Norvaline, acts as a competitive inhibitor of
Arginase while Arginine is converted into NO.
The use of N-carbamylglutamate (NCG) and Arginine-Picamilon is where N0 Extreme’s
NO-boosting power goes above and beyond any other NO product that is sold today.
NCG is an amino acid derivative that has been discovered recently to activate the
release of stored Arginine from endothelial cells into the bloodstream. Additionally,
NCG has been shown to increase protein synthesis and the release of Somatotropin
(human growth hormone) into the bloodstream. The results of clinical trials with
NCG show that it is very safe, even in large doses, and has very profound effects
on muscle growth and protein synthesis.
Arginine-Picamilon is a new innovative compound
from Cellucor that increases blood flow to the brain. Picamilon is bound to Gamma-amino
butyric acid (GABA) via niacin. N0 Extreme’s Arginine-Picamilon works by causing
vasodilation in the brain and an abundance of cerebral blood flow. The GABA moiety
binds the GABA receptor, which is located on the same cells as those that secrete
somatotropin. The activation of the GABA receptor also potentiates the secretion
of Somatotropin, which enhances growth and protein synthesis.
When N0 Extreme stimulates NO, the blood vessels expand in a process known as vasodilation,
which enhances the efficiency at which blood, essential nutrients, amino acids, and
vitamins are delivered to muscle cells, essentially stimulating their growth and
proliferation.
For many decades, the use of branched-chain amino acids, BCAAs, have
caused great gains in anabolic muscle growth. N0 Extreme delivers these essential
amino acids to help harness the anabolic state.
The reason why branched-chain amino
acids are so necessary is because of their role in protein synthesis. BCAAs are the
rate-limiting factors in protein synthesis because of their function in creating
hydrogen bonds within proteins that are responsible for the variations in protein
structure.
The provision of these amino acids by N0 Extreme allows for constitutive
protein synthesis in the body.
N0 Extreme also uses Beta-Alanine and Histidine to form the dipeptide Carnosine and
increase cellular ATP levels very rapidly. Carnosine is known to decrease endogenous
pH levels by decreasing hydrogen ion concentration. This effect increases muscular
endurance and prevents lactic acid build-up. ?eta-Alanine supplementation with Histidine
yields effects very similar to creatine with respect to ATP synthesis without causing
an increase in intra-muscular water levels.
N0 Extreme increases pre-workout energy
levels by providing certain compounds that have never been seen on the supplement
market previously. N0 Extreme takes an athlete to the “next level” of fitness by
harnessing much more energy than it would in a normal state, where the gains go from
impressive to extraordinary.
N0 Extreme addresses the energetic stimulation concept
from three different angles: ATP synthesis via methylxanthines, monoamine secretion
via phenethylamines, and enhancement of the mind-muscle connection.
Methylxanthines are a class of compounds that encompass many simple stimulants with
effects on endogenous ATP levels. N0 Extreme utilizes two particular methylxanthines,
Caffeine and Theobromine, to inhibit cyclic adenosine monophosphate (cAMP) phosphodiesterase.
This inhibition leads to a build-up of cAMP in cells; cAMP becomes phosphorylated
and subsequently causes a sudden surge in ATP levels. In addition, methylxanthines
can cross the blood-brain barrier where they can bind adenosine receptors and cause
a large release of monoamines.
N0 Extreme takes another huge leap in the pre-workout
energy field using Methyltyramine and Methylsynephrine, compounds in a class known
as phenethylamines. Phenethylamines induce psychoactive responses, which then lead
to a physiological response. An example would be the exciting effects felt after
secretion of a large amount of adrenaline, one of the body’s most abundant phenethylamines
as well as a monoamine. The main monoamines in the body are Adrenaline (Epinephrine),
Noradrenaline (Norepinephrine), Serotonin, and dopamine, all of which have specific
effects.
Methyltyramine specifically increases the secretion of norepinephrine and results
in psychological feelings of very intense focus, determination, and goal-oriented
behavior. This compound is also a ß-adrenergic receptor agonist, discussed below.
Methylsynephrine is more specific for Adrenaline and is similar to Ephedrine. Coincidentally,
Methylsynephrine and Ephedrine differ only by one chemical substituent, a hydroxyl
group, on its phenyl ring.
Both Methyltyramine and Methylsynephrine are ß-adrenergic
receptor agonists. When these receptors are activated, a very interesting cascade
of events ensues. The body begins a series of “fight or flight” responses, including
increased heart rate, increased muscle blood flow, increased muscular thermogenesis,
increased fat metabolism, and increased ATP levels. Metabolically, the stimulation
of the ß-adrenergic receptors has many benefits such as increased muscle growth,
decreased body fat, and overall feelings of wakefulness and clarity of the mind.
In combination with the effects of the Methylxanthines and phenethylamines, N0 Extreme
takes it one step further by the use of Vinpocetine. Vinpocetine is a very unique
compound that causes vasodilation of vessels in the brain and muscles simultaneously.
Many clinical trials have shown that it also increases mental and cognitive functions
and mind-muscle coordination.
Like many other Cellucor products, N0 Extreme regulates
blood sugar by enhancing insulin sensitivity. Through N0 Extreme’s use of Oxovanadium,
the body’s response to blood sugar results in the formation of more intra-muscular
glycogen than the storage of body fat. Oxovanadium, in very small dosages, mimics
insulin’s activity in muscle by converting excess glucose into glycogen, a storage
form of sugar within muscles, as opposed to the storage of excess sugar as fat. The
modulatory effects of Oxovanadium result in a drastic increase in muscular power
and endurance.
